Open diagnostic platform — AMR & infectious disease
An open-source AI pipeline that identifies infection type, pathogen, and antibiotic resistance profile from whole blood — in hours, not days.
The problem
Antibiotic resistance is projected to cause 39 million deaths between 2025 and 2050.
A root cause is diagnostic imprecision. When clinicians cannot quickly distinguish bacterial from viral infection, they prescribe antibiotics unnecessarily — accelerating resistance. Existing tests are slow, siloed, and inaccessible in low-resource settings. OpenGenDx exists to fix this.
The approach
Machine learning identifies optimal combinations of host and pathogen genes from public genomic datasets — finding diagnostic patterns no single marker could achieve.
A single multiplex PCR test across fluid types — blood, CSF, urine — returning infection diagnosis, pathogen identity, and resistance profile in 1–2 hours.
Free for public health systems, academic institutions, NGOs, and low-income countries. Sustainably licensed for commercial use — with revenue funding free global access.
Roadmap
AI-driven gene panel discovery across 8 geographically diverse sepsis cohorts. LODO cross-validation, permutation testing, and defensive publication establishing prior art.
CompleteIndependent expert review, bioRxiv preprint submission, expansion to underrepresented cohorts (sub-Saharan Africa, South Asia), and wet lab validation of the gene panel.
NowMultiplex PCR panel design from validated genes. Pilot deployment in low-resource clinical settings. Regulatory pathway for use across blood, CSF, urine and synovial fluid.
NextThe same genomic knowledge base powers AI-assisted CRISPR sequence design — targeting resistant pathogens that antibiotics can no longer reach.
BuildingGet involved
Currently seeking bioinformaticians, clinical microbiologists, global health researchers, and biosecurity specialists. If the mission resonates, get in touch.
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